ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Int J Obes (2005) 2018; 42(11):1834–1844This paper presents the results of a multidisciplinary expert workshop to identify current knowledge and more importantly current gaps in knowledge on the epidemiological and biopsychosocial determinants of obesity and its optimal treatment approaches.Childhood obesity is a global ...

Diabetes Care. 2020 Oct;43(10):2544–2552. doi: 10.2337/dc19-2164. PMID: 32778556.In brief: This cross-sectional study compared bone mineral density (BMD), lean body mass and abdominal visceral fat between 180 individuals with T2DM, 226 with obesity, and 238 with normal weight, aged 10–23 years. The findings suggest that T2DM in youth may have a detrimental effect on bone accru...

To read the full abstract: J Pediatr 2018;202:143–149.Summary: In a case control study of 30 post-institutionalized youths compared with 90 age- and BMI percentile-matched youths living in the Minneapolis-Saint Paul metropolitan area, early life stress, as reflected by height-stunted growth in institutional care, was associated with cardiovascular and metabolic risk in yout...

Lusc0001@umn.edu Obesity (Silver Spring) 2022, 30(5):1105–1115. https://doi.org/10.1002/oby.23395Brief Summary: This 52-week randomised placebo-controlled trial showed that exenatide XR improves stabilisation of BMI reduction after lifestyle intervention in adolescents with obesity.Maintaining weight loss after an in...

To read the full abstract: N Engl J Med. 2020;382(22):2117–2128. doi: https://pubmed.ncbi.nlm.nih.gov/32233338/Kelly et al. randomly assigned (1:1) n =251 obese adolescents (age 12 to <18 years) to receive either liraglutide (3.0 mg), a long-acting glucagon-like peptide-1 agonist, or placebo subcutaneously once daily in addition to lifestyle therapy. Liraglutide w...

To read the full abstract: J Bone Miner Res 2018;33:430-436Bone mass increases dramatically during puberty. The process of sexual maturation is therefore likely to impact lifelong bone health. Bone mineral density (BMD) tracks throughout life and later age at menarche is associated with increased osteoporosis risk in women, possibly because of combined effects of later menarche and lower peak bone ma...

To read the full abstract: Int J Obes (Lond). 2018 Jan;42(1):102-107This cohort of n=50 adolescents who underwent bariatric surgery is highly important, since such long-term follow-up data are rare. Until today, only this study cohort described here by Ryder et al. and the Swedish nationwide study (AMOS) of adolescents with severe obesity who underwent laparoscopic Roux-en-Y gastric bypass (3) hav...

Brief summary: This phase 3 double-blind, parallel-group, randomized, placebo-controlled trial over 68 weeks randomised (2:1) 201 adolescents with obesity to receive semaglutide 2.4 mg once weekly or placebo. Both groups also received lifestyle intervention. The primary endpoint was the percentage change in BMI. Treatment with semaglutide produced clinically relevant reductions in BMI and body weight, and improvements in cardiovascular risk factors, which were all significantl...

Nat Med. 2022;28(4):814-22. doi: 10.1038/s41591-022-01714-5.PubMed ID: 35314841Brief summary: This study performed large-scale metabolomic profiling across 14 000 adults from 4 cohorts and identified 17 steroid metabolites whose levels were reduced in individuals with prevalent asthma. The largest reductions were associated with inhaled corticosteroid (ICS) treatment, and these were valida...

In Brief: This multicenter, randomised controlled trial in 156 adults (mean age 44 years) with type 1 diabetes (T1D) showed benefits of intermittently scanned continuous glucose monitoring (CGM) (intervention) compared to usual monitoring of blood glucose levels by fingerprick testing on: lower HbA1c (−0.5%; P<0.001), 130 minutes/day longer duration of ‘in target’ glucose levels, and 43 minutes/day shorter time spent with hypoglycaemic blood glucos...